Cystinuria is a rare inherited condition characterized by the abundance of cystine in the urine, which leads to the formation of cystine crystals and stones in the kidney, ureter, and bladder.¹

Cystine stones are recurring, and can cause sharp pain in the side, pain while urinating and blood in the urine.¹

Cystinuria is a lifelong condition, in which cystine stones tend to reoccur. To reduce the chances of cystine stone formation, healthcare providers recommend drinking lots of water, making dietary adjustments and reducing salt intake.²

VENXXIVA is a prescription medication provided in a delayed-release tablet. It is used in combination with high fluid intake, alkali (low acid), and dietary changes to help prevent the formation of one type (cystine) of kidney stones in certain adult and pediatric patients nine years of age and older and who do not respond to these measures alone.³

VENXXIVA is available in 100 mg and 300 mg dose strengths. VENXXIVA (tiopronin) Delayed-Release Tablets must be taken without food.³

VENXXIVA is the same proven tiopronin as THIOLA EC®,³ accompanied by our dedicated patient support program* Cycle Vita.

VENXXIVA is the same proven tiopronin at generic coverage, but is accompanied by Cycle Vita, our dedicated patient support program which will provide product and process support* at every step of your treatment.

VENXXIVA (tiopronin) Delayed-Release Tablets must be taken without food, because tiopronin absorption is better when taken without food.³

For more information about taking VENXXIVA, see here.

Yes, VENXXIVA is indicated for pediatric patients nine years of age and older.³ Children must weigh at least 20 kg, or 44 lbs, and are able to swallow tablets whole.

Cycle Vita is our dedicated patient support program, which offers product and process support* at every step of your VENXXIVA treatment.

Throughout your VENXXIVA treatment, you can expect to hear from two types of people at Cycle Vita:

Access Specialists – help you access VENXXIVA through enrollment, financial and pharmacy support.*

Clinical Education Managers – provide you with clinical education, product support, and dietary and nutritional support.*

To contact Cycle Vita, please call 888-360-8482 or email hello@cyclevita.life.

Bridge Program:* A free supply of VENXXIVA so you can begin therapy while Cycle Vita secures appropriate Benefit Verification and assists with Prior Authorization. Bridge duration is driven by insurance coverage and the active collaboration of your clinic.

Co-Pay Assistance Program:* If you are eligible, you may pay as little as $0.

Continuous Clinical Product Support:* On-going support in managing the VENXXIVA therapeutic routine including clinical education, onboarding, and medication adherence.

Patient Nutrition Program:* A dietitian will provide on-going guidance and education to assist you with your clinic’s nutrition plan, specific to cystinuria.

Reimbursement Research Support:* Assistance in securing coverage.

To find out more about eligibility criteria please contact Cycle Vita at 888-360-8482.

As soon as Cycle Vita receives a completed enrollment form from your healthcare provider, we will get to work and reach out to you to take next steps.

If you are eligible,* Cycle Vita will provide individualized support, such as financial and pharmacy support, as well as clinical education, dietary and nutritional support, specific to cystinuria.

If you are a commercially insured eligible patient who has been prescribed VENXXIVA, you may pay as little as $0 in co-pay.* To find out more about eligibility criteria please contact Cycle Vita at 888-360-8482.

If you are eligible, Cycle Vita will provide you with a temporary free supply of VENXXIVA while your insurance coverage is being determined, through the Bridge Program.*

Through Cycle Vita, eligible* patients prescribed VENXXIVA will have access to the Bridge Program, which provides a free supply of VENXXIVA to diagnosed patients to allow you to begin therapy immediately while Cycle Vita secures appropriate Benefit Verification and assists with Prior Authorization.

The Bridge Program may also be requested if you are an existing patient who is temporarily experiencing disruption in therapy due to insurance coverage. Bridge duration is driven by insurance coverage and the active collaboration of your clinic.